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The mechanisms associated with the effects of opiates or opioid medications are reviewed elsewhere ( Although the classical pharmacological approach to treating the pylorus in gastroparesis involves botulinum toxin injection and there is open-label experience to suggest efficacy especially with higher dose injections (Coleski et al., 2009), two placebo-controlled trials did not demonstrate efficacy (Friedenberg et al., 2008)
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Increased levels of 8-OHdG and isoprostanoids have been observed in the urine of subjects affected by the disease compared to the control group (Miller et al., 2014)
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