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These changes are further accompanied by marked reductions in astrocyte-secreted extracellular matrix (ECM) proteins, such as laminin or heparan-sulfate proteoglycan (Lasek, 2016

It explains how the Agency assessed the medicine to recommend its authorisation in the EU and its conditions of use

SITAGLIPTIN PHOSPHATE + METFORMIN HCl (JANUMET) is indicated as part of triple combination therapy with a sulfonylurea as an adjunct to diet and exercise in patients with type 2 diabetes mellitus inadequately controlled with any two of the three agents: Metformin, sitagliptin, or a sulfonylurea

Kite believes this approach may offer a more durable and long-lasting therapeutic effect