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Gao K, Mu CL, Farzi A, Zhu WY

Animal As a senolytic, FOXO4-DRI carries mechanism-specific theoretical risks discussed in the senescence literature including disruption of beneficial senescence surveillance and off-target effects on stem-cell populations that share features with senescent cells and senolytic translation from mouse to human has a history of failures

Growing global demand for GLP-1 medicines has increased interest in affordable alternatives, particularly in countries where access has been limited by the high cost of branded therapies

Expanding research scope (20252026): New studies in neuroprotection and pancreatic islet cell senescence (Nature, 2025)