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GLP-1 RAs not only ameliorate insulin resistance and microvascular injury [84], which are significant determinants of depression in T2DM, but also enhance dopamine metabolism and stimulate growth factor signaling pathways, suggesting potential neuroprotective functions [85,86]
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Tirzepatide (Zepbound) and orforglipron (Foundayo) carry the most explicit labeling on this point
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