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10.1161/CIRCRESAHA.117.311401 23 GharagozlooP.Gutirrez-AdnA.ChamprouxA.NoblancA.KocerA.CalleA.et al (2016)
If side effects are severe, prescribers may slow titration, reduce doses, or adjust treatment approaches
This leads to impaired bacterial clearance and contributes to the immunosuppressive state of sepsis, while mice lacking IRAK3 exhibited improved host defense and survival (Deng et al., 2006)
this risk is known to increase with age, and is more common in women (1.5 times compared with men) (35)
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