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For patients whose disease progresses on these regimens, alternative regimens or second-line options, such as liposomal irinotecan combined with 5-FU, may be considered if not previously administered [24]
Kang, L., Chen, M., Huang, J
AI Statement This manuscript was supported by the use of a large language model (ChatGPT, OpenAI) for language editing and formatting assistance
While the research base for microdosing, specifically, is still developing, and lower-dose protocols are being explored, though clinical evidence for efficacy at sub-therapeutic doses remains limited
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