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Owing to the rapid degradation of GLP-1 by dipeptidyl peptidase type 4 (DPP-4), it is structurally modified into more stable GLP-1R agonists, such as liraglutide, exenatide, and dulaglutide, which share 97%, 53%, and 90% sequence homology, respectively 12

Potential risks and side effects: Nausea Gastrointestinal discomfort Allergic reactions Side effects of supplementation are usually mild and tend to subside as the body adjusts to the supplement

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The combination is studied together for synergistic effects in non-clinical research models