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In addition to the relevance of POP conjugation cited previously, hyperglycemia and hyperinsulinemia appear to directly inhibit glutathione synthesis (GCL), and the increased production of reactive oxygen species which accompanies diabetes further depletes GSH levels
doi:10.1111/j.1523-1755.2002.kid558.x Liu G, Yu L, Fang J, Hu CA, Yin J, Ni H, Ren W, Duraipandiyan V, Chen S, Al-Dhabi NA, Yin Y (2017) Methionine restriction on oxidative stress and immune response in dss-induced colitis mice
The p53(3KR) mutant, lacking acetylation due to lysine-to-arginine substitutions at three residues, decreases expression of SLC7A11 without affecting other p53 targets such as CDKN1A/p21 (involved in cell cycle progression) or BAX (involved in apoptosis)
As a result, a comparison of the two independent transcriptomics experiments reveals stable associations between specific proteins of thiamine/ThDP metabolism and ThDP-dependent enzymes in enterocytes
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