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& Zhu, J.-Z

npj Metab Health Dis 3 , 26 (2025)

Alpha-1 antitrypsin (AAT) deficiency, which is common in European and North American populations 55,56 , delays the inhibition of neutrophil elastase, consequently enhancing activation of the D614G S protein and facilitating host cell entry of the D614G SARS-CoV-2 variant 57

This can damage or destroy insulin receptors and increase the risk of type 2 diabetes ( Animal studies show that NAC may stabilize blood sugar by decreasing inflammation in fat cells and thereby improving insulin resistance ( When insulin receptors are intact and healthy, they properly remove sugar from your blood, keeping levels within normal limits