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This can be particularly important for patients with a history of heart disease or those at high risk

Studies show: ~13% reduction in cardiovascular death Lower rates of heart attack and stroke Meaningful improvements in kidney outcomes Initial evidence suggests that these benefits extend beyond diabetic populations, further broadening the underwriting implications

NICE guidance (NG28) on type 2 diabetes management recommends dose reduction of sulphonylureas or insulin when initiating GLP-1 receptor agonist therapy to mitigate this risk

Electrolytes, particularly sodium, potassium, and magnesium, are lost alongside fluids during GI episodes and need to be replaced