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In isolated cardiomyocytes, GLP-1 receptor agonists activated PI3K/Akt, AMPK, and cAMP/PKA pathways while reducing NOX4-mediated oxidative stress, signalling cardioprotective effects by alleviating ER stress-induced apoptosis [51]
In addition, the impact of the collagen supplement was assessed in human dermal fibroblasts for collagen type I, elastin, and proteoglycan biosynthesis
Antioxidant and metal-chelating effects of polyamines
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