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What may be a good way to think of that is its the Achilles heel for certain cancers: they have one gene that drives their growth
At this stage, VSMCs not only lose contractile phenotype but also acquire macrophage-like and inflammatory characteristics, secreting factors such as IL-1 and MMPs that exacerbate plaque instability
The emerging challenge is no longer whether we can produce profound metabolic benefits, but rather how to optimise durability, individualise receptor targeting and translate these complex pharmacologic innovations into long term clinical decision making
[5] [11] Clinical trials have demonstrated significant weight loss with these medicationstypically 15% with semaglutide 2.4mg (Wegovy) and 5-8% with liraglutide 3.0mg (Saxenda) over 68 weekswhen used alongside dietary changes and physical activity advice
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