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There is no clinical evidence that vitamin B12 pills cause weight loss in people with normal B12 levels, and neither NICE nor the NHS recommends them as a weight management intervention

According to the ASPS 2024 Procedural Statistics Report, over 800,000 aesthetic patients in 2024 reported using GLP-1 weight loss medications

Adipose tissue is an endocrine organ that responds to obesity by secreting elevated quantities of free fatty acids, adipokines, and proinflammatory cytokines, triggering IR and risk of T2DM [8]