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This is probably due to another aspect of IGF-1 its binding proteins

Vitamin C helps recycle Glutathione inside cells, enhancing its antioxidant capacity

Of note, folate recommendations in the US and certain other countries are now expressed as Dietary Folate Equivalents (DFEs), a calculation that was devised to take into account the greater bioavailability of folic acid compared to naturally occurring dietary folates (see The RDA)

Healthcare provider sign-off: If you take any prescription medication for glucose management, diabetes, cardiovascular conditions, or hormone-related conditions, have you discussed adding a botanical supplement with your provider