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However, the FDA label explicitly states that "it is unknown whether GLP-1 receptor agonists cause thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans, as the human relevance of GLP-1 receptor agonist-induced rodent thyroid C-cell tumors has not been determined." The rodent thyroid has substantially more C-cells than the human thyroid, and rodents may be more susceptible to this effect

The chronic low-grade inflammation driven by visceral belly fat releases inflammatory chemicals TNF-alpha and IL-6 are the most-named which generate oxidative damage in your tissues

What they did: Obese mice received AOD-9604 orally (via gavage) for 14 days at various doses (50, 250, 500 g/kg)

2003 February;17(1):27-33