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Treg dysfunction might exaggerate local inflammation and stimulate angiogenesis by interacting with effector T cells and macrophages, thereby facilitating the attachment and growth of endometrial implants and increasing the risk of reproductive and perinatal complications

The GSH:GSSG ratio is a widely used biomarker of cellular oxidative stress, with depletion implicated in neurodegeneration, hepatic injury, and immune dysfunction

While autophagy is normally a protective mechanism, Erastin subverts this process to promote ferritinophagy, leading to the large-scale degradation of ferritin and the release of excess iron that further reinforces ferroptosis