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The capsule is chemically engineered to remain intact through the stomach's acidic environment and dissolve only in the small intestine the optimal site for bicarbonate absorption
Sharing a 94% structural homology with native human GLP-1, Semaglutide is distinguished by three modifications: 1) amino-acid substitutions at position 8 (alanine to -aminoisobutyric acid or Aib) and position 34 (lysine to arginine), and acylation of the lysine in position 26 with a spacer consisting of two 8-amino-3,6-dioxaoctanoic acid (ADO) moieties, a glutamic acid moiety, and a C-18 fatty di-acid side chain (Lau et al., 2015)
They are not dosing recommendations or validated route conversions
The mechanism of action involves the sulfur (thiol) groups in glutathione molecules, which actively scavenge reactive oxygen species (ROS) and free radicals within cells
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