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Unloaded drugs and organic solvent were removed through dialysis against deionized water for 48 h

The AKT pathway can phosphorylate more than fifty substrate proteins and modulate processes disrupted in PD, such as the enhancement of synapse formation, autophagy, and LTP, as well as inhibiting the secretion of pro-inflammatory cytokines, apoptosis, microglial activation, tau phosphorylation and the accumulation of -synuclein and A (Fig

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However, what began as a metabolic therapy is rapidly evolving into one of the most promising classes of peptide therapeutics across multiple disease areas