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Researchers found that those in the treatment group had a greater decrease in kidney function and an increase in vascular events, including heart attack and stroke
PMID 17284744
If you often feel fatigued, struggle with brain fog, or notice changes in your mood and metabolism, a vitamin deficiency might be to blame
Stronger mechanistic clarification would require isoform-specific NOS inhibition, direct measurement of NO metabolites, eNOS phosphorylation analysis, rescue experiments, and comparison across endothelial, epithelial, fibroblast, and neuronal model systems
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