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O (Outcome): Primary outcome: changes in serum Vitamin B12 levels, clinical improvement of Vitamin B12 deficiency symptoms
The principle was proven yet again in 2008, when Bitonti and colleagues showed that also small FcRn-binding peptides could increase the catabolism of IgG in both mice and NHPs [117]
However, experimental treatments may not be covered
Administering at a similar time each night helps in aligning with the bodys circadian rhythm and supports sleep-wake cycle stability
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