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In clinical trials, 11%21% of people on Zepbound experienced constipation
Thus, we feel this can only be explained through a change in energy expenditure, and, since skeletal muscle is the primary target of GDF8, we hypothesize the change in energy expenditure is coming from this compartment
Senescent fibroblasts and endothelial cells, through the secretion of SASPparticularly PDGF-Apromote an increase in myofibroblast numbers at wound sites, which positively affects wound healing [141]
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