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Primary outcome (major adverse cardiovascular events) occurred in 12.0 percent of the semaglutide group versus 13.8 percent with placebo This corresponds to a 14 percent relative reduction in risk Absolute reduction in risk was 2.0 percent over 3 years Number needed to treat to prevent one event: 50 patients Nonfatal heart attacks occurred in 4.0 percent with semaglutide versus 5.2 percent with placebo Stroke and death from cardiovascular causes were slightly lower but not statistically different Kidney outcomes were directionally better with semaglutide but not statistically significant Additional benefits with oral semaglutide Lower average blood sugar (hemoglobin A1c reduced by 0.71 percent vs

Tim-Aroon T, Harmon HM, Nock ML, Viswanathan SK, McCandless SE

Gradual dose titration, as recommended in prescribing guidelines, helps minimise these effects

Some studies even suggest B12 can naturally support healthy cholesterol levels and overall cardiovascular health