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B vitamins are needed for healthy skin, hair, eyes, and liver
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By day 75, fewer than 50% of homozygous mice survived (Figure 5D)
This effect was previously documented in the DCCT and UKPDS trials and occurs regardless of the treatment method used (insulin, oral agents, or GLP-1 medications), reflecting changes in retinal blood flow and vascular permeability during metabolic adjustment
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