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"The freezing step in lyophilization: physico-chemical fundamentals, freezing methods, and consequences on process performance and quality attributes of biopharmaceuticals." European Journal of Pharmaceutics and Biopharmaceutics

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Over-the-counter topical hydrocortisone cream (0.5-1%) may be used sparingly for persistent localized itching for short-term relief after discussion with a healthcare provider

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Osmotic laxativessuch as polyethylene glycol (Miralax), magnesium citrate, and lactulosework by drawing water into the stool and are generally considered first-line options alongside semaglutide

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