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Some research has even found that using BMI to determine treatment may end up excluding a significant number of adults who have weight-related health conditions, such as metabolic syndrome
The potential therapeutic benefits of blocking A 2A receptor signaling in microglia appear broadly applicable across neurodegenerative diseases
In a statement to Insider, Novo Nordisk, the company that makes Wegovy and Ozempic, said that Gila monsters and the discovery of exendin-4 "did not have anything to do with our decision to develop long-acting GLP-1 receptor agonists" for obesity, because "that was based on GLP-1 biology in humans." But the company also said that "the GLP-1-like effect of exendin-4" in Gila monsters was "an important contribution to the field," as it led to the development of the very first injectable drug of its kind
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