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doi: 10.1007/s12035-022-03201-x 46 FujitaY.FujitaA.IshimaT.HiraiA.SuzukiS.SuganumaH.et al
Analyzing the molecular mechanisms of repair and regeneration in several different liver diseases, including AILI, NAFLD/NASH, ALD, viral hepatitis, and age-related conditions, and identifying commonalities and distinct features will contribute to a better understanding of the repair process and the development of targeted and optimized therapeutic interventions
Nevertheless, the interaction between LC3, SQSTM1, and Keap1 still remains controversial, as the binding competition to SQSTM1 between Keap1 and LC3 can be attributed to the spatial adjacency of the LIR domain and KIR domain in SQSTM1 (Zhang et al., 2021)
RCT (PMID 24791752)
