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Decreasing ectopic lipid accumulation also may promote insulin sensitivity [13]
Semaglutide's long-term effects in obesity patients include sustained weight loss averaging 15-20% over two years, improved cardiovascular health markers, enhanced insulin sensitivity, and reduced inflammation levels
Specific escalation schedules varied by trial protocol, and the full range of doses studied is described in the published Phase 2 trial data
Traditional weight loss approaches frequently fail during this transition
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