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In a separate follow-up Phase IIa study over 49 days, the mechanism of improved glucose metabolism was shown to be a combination of enhanced insulin secretion and delayed gastric emptying [83]
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A double stranded small-interfering RNA (siRNA) to the ANGPTL3 mRNA, that is conjugated to GalNAc (identified as ARO-ANG3), has shown promise at hepatocyte-specific reduction in ANGPTL3 mRNA levels
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