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Both TIn and Alk-TIn strongly inhibited the activity of mTYR with IC 50 values of 51.1 nM and 92.6 nM, respectively, which were both much lower than the commercial TYR inhibitor kojic acid (34.1 M) (Supplementary Fig
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In some cases, an electrocardiogram test will pick up an abnormal heart rhythm before a dog develops symptoms
Proteintech, Rosemont, IL, USA) were used for western blotting
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