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Contrave is a prescription combination of naltrexone and bupropion that targets two areas of the brain involved in appetite and cravings: Bupropion activates neurons in the hypothalamus that naturally suppress appetite -Naltrexone blocks the brains counter-signal that would normally mute that appetite suppression Together, they keep the appetite-reducing effect switched on longer than either drug achieves alone The result is a reduction in food cravings, less reward-seeking behavior around eating, and for many patients, a quieter mental relationship with food without relying on stimulants or gut hormone changes.Heres the key mechanism: the hypothalamus is the part of your brain that regulates appetite and energy balance

They are primarily prescribed for managing chronic metabolic conditions like Type 2 diabetes and clinical obesity

Oftentimes, patients who undergo weight loss surgery have low B12 levels, which can cause fatigue

Efficacy and safety of LixiLan, a titratable fixed-ratio combination of lixisenatide and insulin glargine, versus insulin glargine in type 2 diabetes inadequately controlled on metformin monotherapy: The LixiLan proof-of-Concept randomized trial