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They're also supposed to promote gut and immune system health
The discussion is best framed as a potential increased risk related to dehydration and rapid weight loss, balanced against the likely long-term benefits of improved metabolic health
Other GLP-1 receptor agonists (such as dulaglutide or liraglutide) have different pharmacokinetic profiles and may be better tolerated
Side Effects Compared Both share similar GI side effect profiles since they both activate GLP-1 receptors: Tirzepatide generally shows lower GI side effect rates in trials, possibly because GIP receptor activation provides a "smoother" signaling profile than pure GLP-1 agonism
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