The STEP-1 body-composition substudy (n=140 DXA cohort) of semaglutide (Wegovy at 2.4 mg weekly) reported fat-free mass loss of approximately 6.9 kg over 68 weeks, accounting for approximately 45% of total weight loss based on the body-composition substudys own arithmetic and the Conte 2024 systematic review [6, 7]
In addition, Irg1-deficient phagocytes, which cannot produce itaconate, have shown increased susceptibility to M.tb infection, with infected mice exhibiting higher bacterial loads, reduced survival, exacerbated inflammation, extensive necrotizing granuloma formation and elevated neutrophil infiltration in the lungs [104, 105]
The early clinical data is suggestive, and the research community continues to investigate their potential applications
Insights gained by Black Swan Data, using its self-serve consumer intelligence platform, show that GLP-1-related online conversations frequently connect to weight management and weight loss, and that many participants are focused on muscle-building and recovery, and getting more protein into their diets