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So, you measure a higher B12, but part of that B12 is inactive, so useless Oral B12 supplementation, even in the form of a multivitamin preparation, may result in serum B12 concentrations just within the normal range without abolishing symptoms

Also, NF-B is a key regulator of several genes, including MMP-9, COX2, c-Myc, cyclin-D, etc