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However, current evidence is primarily derived from in vitro models or animal studies, and often relies on indirect indicators such as protein expression changes (e.g., LC3-II, Beclin-1)

Thermosensitive hydrogels are viewed to be a promising drug therapies while many polymers are temperature-responsive to phase transitions, with solgel transitions occurring in response to temperature changes during injection [110,111,112]

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360 In HCC, stabilizing ferritinophagy mediators such as NCOA4 using deISGylation inhibitors such as hypericin can restore ferroptotic sensitivity and overcome resistance to agents such as sorafenib