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This systemic effect simply cannot occur with topical application
The synergy between exogenous MOTS-c and exercise is not merely additive: because MOTS-c mimics one of the molecular consequences of high-intensity exercise (AMPK activation via AICAR accumulation), concurrent exercise training may amplify the peptide's effects on GLUT4 translocation and mitochondrial biogenesis
Gopal S, Kumar C, Taranath V, Venkatamuni A, Vardhan R (2015) Therapeutic potential of Carica papaya l
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