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Figure 4 Due to the influence of renal clearance and dipeptidyl peptidase-4 (DPP-4), GLP-1 has a short natural half-life in the human body, about 12 min (113)
OMP continues to be converted into orotidine monophosphate (UMP) and then uridine triphosphate (UTP), which is then converted into CTP by cytidine triphosphate synthetase (CTPS) via utilizing the amide group on glutamine (Figure 1)
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After centrifugation, the medium was removed and replaced with fresh growth medium
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