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Truncated GLP-1 (proglucagon 78-107-amide) inhibits gastric and pancreatic functions in man

Contrave is a prescription combination of naltrexone and bupropion that targets two areas of the brain involved in appetite and cravings: Bupropion activates neurons in the hypothalamus that naturally suppress appetite -Naltrexone blocks the brains counter-signal that would normally mute that appetite suppression Together, they keep the appetite-reducing effect switched on longer than either drug achieves alone The result is a reduction in food cravings, less reward-seeking behavior around eating, and for many patients, a quieter mental relationship with food without relying on stimulants or gut hormone changes.Heres the key mechanism: the hypothalamus is the part of your brain that regulates appetite and energy balance

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Gut dysbiosis can lead to higher concentrations of these hormones, which can inhibit hormone signaling and alter energy metabolism ( N Engl J Med , 2024)