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5 Based on their findings, Carroll and Kelley advise that until more rigorous studies (randomized, controlled trials with diverse menopausal patient populations at least 12 weeks in duration or longer) are conducted to assess their use in the management of hot flashes, duloxetine, escitalopram, fluvoxamine, and mirtazapine (see below) should be reserved as last-line therapy
Meng J, Lv Z, Zhang Y, Wang Y, Qiao X, Sun C, et al
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