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More specifically speaking, GLP-1 receptor activation facilitates the presynaptic release of GABA into RGCs via the Gs/cAMP/PKA/Phospholipase C (PLC)/IP3/Ca2+/CaM signaling pathway, ultimately increasing the GABAergic miniature inhibitory postsynaptic currents (m-IPSCs) frequency and contrast sensitivity (Shao et al., 2024)

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The injection site may be numbed with a local anesthetic to minimize discomfort

In practical terms that means deeper sleep, better recovery, improved body composition, and over months, meaningful shifts in lean muscle, fat distribution, skin quality, and overall steady-state energy