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Proteins encoded by ALG2 , STT3A, STT3B , PRKCSH , MLEC , CALR , and UGGT1 of the lectin-dependent folding process, PDIA3 , PDIA6 , ERO1L, TXNDC5 , regulating disulfide-redox protein folding, and by PSMC2, PSMD2, PSMD4, PSMD6 , the proteasome subunits associated with protein degradation of improperly folded proteins, were all more abundant in UGT2B17-deficient livers (Supplementary Table 1)
The occurrence of hepatic stellate cells can activate hepatic stellate cells and further induce their proliferation, synthesize a large amount of cell matrix, and deposit in the extracellular space, ultimately causing liver fibrosis [40, 41]
Potential Weight Management: While still under study, GIP medications could offer new avenues for weight management, particularly through their effects on fat metabolism
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