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This connection becomes significant because it affects our brains areas that control eating behavior and emotional responses

Metformin is contraindicated when eGFR falls below 30 mL/min/1.73 m2 and dose reduction is recommended when eGFR is 30 to 45 mL/min/1.73 m2, per the FDA Drug Safety Communication (2016)

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GLP-1 helps people feel satiated, so they can more easily reduce calorie intake