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Wong, T

The local GI argument is the strongest case for capsules, but it is rarely explained correctly If BPC-157 is degraded locally in the gut lumen and acts on GI epithelial receptors before degradation, then high oral bioavailability is not required for a GI-local effect

This is a mechanistically reasoned hypothesis being tested cautiously by forward-leaning practitionerswith all the risks that implies

The reason this ingredient is so effective is because it forms a thin film on the skin that reduces transepidermal water loss (TEWL) while supplying linoleic acid to the stratum corneum to improve barrier strength