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A glutamine residue replaces asparagine at position 8, a modification that may reduce spontaneous chemical rearrangements or hydrolysis of the peptide backbone

In breast cancer, where EGFR inhibitors such as erlotinib are being used to inhibit the EGFR signaling pathway, IGF-1R confers resistance by forming one half of a heterodimer (see the description of EGFR signal transduction in the erlotinib page), allowing EGFR signaling to resume in the presence of a suitable inhibitor

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It is initiated by the activation of inflammasomes, which activate inflammatory caspases (such as caspase-1, -4, -5, and -11), leading to cleavage of Gasdermin D (GSDMD)