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Jan 20, 2026 9 min read READ MORE Fitness GLP-1 and Strength Training: Avoiding a Common Pitfall Losing weight on a GLP-1 medication

In male db/db mice, an increase in short-chain fatty acid (SCFA)-producing bacteria (such as Parabacteroides, Oscillibacter, and Prevotellaceae) coincides with a reduction in pro-inflammatory genera (like Anaerotruncus and Lachnospiraceae) and a positive change in alanine aminotransferase/aspartate aminotransferase (ALT/AST) levels, thereby establishing a clear connection between changes in the microbiome and metabolic as well as liver health benefits [41-43]

Semaglutide and tirzepatide work by targeting the hormones that control hunger, helping you feel full longer and reducing cravings