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Risk of bias assessment The Cochrane Collaborations risk of bias tool was employed to assess the risk of bias for each study (Reference Higgins, Altman and Gtzsche19)

Injectable GLP-1 medications can be given at any time, but oral semaglutide (Rybelsus) also requires fasting administration, so consider bedtime levothyroxine dosing with careful TSH monitoring

Effects of GLP-1 receptor agonists on biological behavior of colorectal cancer cells by regulating PI3k/Akt/mTOR signaling pathway