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Individuals on Tirzepatide (n = 50) reported a median dose of 7.5 mg [range 0.515 mg], and on Semaglutide variants: Ozempic or Wegovy (n = 54) reported a median dose of 1 [range 0.252.4] and Rybelsus (n = 2) reported doses of 7 mg and 14 mg

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178 Despite substantial progress in targeted therapies and immunotherapies, both intrinsic and acquired resistance continue to limit durable responses

Treatment compliance was assessed and reinforced through drug accountability information (counting returned tablets) and through documented discussions with participants and study partners