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There are also concerns regarding potential drug-interactions and a reduction in long-term efficacy due to tachyphylaxis [73]
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Our evaluation considers: Manufacturer experience and transparency Current good manufacturing practices Raw-material identity and sourcing Finished-product specifications Potency and contaminant testing Stability and packaging Formulation rationale Evidence proportional to marketing claims Clinical usefulness and patient tolerance We have personally toured leading private-label supplement manufacturers to better understand their sourcing, testing, production and quality-control systems
The reactions reported ranged from relatively mild findings to less common but more significant skin reactions
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