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Considering again that the myogenic stem cell activator HGF is found in an ECM-bound state 19,20,21,22,26 and undergoes nitration of tyrosine residues (Y198 and Y250) with aging 32,32,62 and muscle disuse (Kuwakdo et al., 2025), the present in vivo experiments provide a robust platform showing the potential for LASSS that could efficiently reduce or delay the nitration-dysfunction of ECM-bound HGF under peroxynitrite-generating conditions

state that despite a paucity of supporting evidence, many experts will tolerate a few daily seizures to mitigate the risk of complications associated with profound sedation. (38117319) [#4] lift sedation to determine if seizures can be controlled off anesthetic infusions Anesthetic infusions are weaned off (while continuing maintenance antiseizure medications)