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I will say there are a lot of anecdotal reports about initial insomnia and elevated heart rate (presumably lowered HRV) on the forums, and I did experience that when starting tirzepatide and when trying retatrutide, but the insomnia and heart rate issues seemed transient
Kaur P, Ghariwala V, Yeo KS, Tan HZ, Tan JCS, Armugam A, Jeyaseelan K (2012) Biochemistry of Envenomation
Methylcobalamin is often taken to improve cardiovascular problems, cognitive impairments, behavioral issues, and circadian rhythm disturbances such as insomnia
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