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To date, editing technologies, such as CRISPR/Cas9, have been used to edit mismatched HLA in iPSC cells to construct HLA-matched iPSC libraries ( in vitro for a long period of time are too fragile to undergo additional gene editing via CRISPR/Cas9
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Dhaouadi N, Vitto VAM, Pinton P, Galluzzi L, Marchi S
But what it found was not ambiguous
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